Apart from the inclusion of anti-CCP status, the main methodological departure from the original study was the use of the van der Heijde modified Sharp radiograph scoring system, which is more sensitive for detecting temporal radiographic change in early RA [ 6].
Various radiographic signs were noted, including erosion, coarse trabeculae, and apparent lack of any radiographic change, and CT scans featured cystic expansion of alveolar process with broken cortex.
For instance, a subgroup of individuals with knee osteoarthritis (those with higher pain intensity but minimal radiographic change in the knee) exhibiting strong sensitization has been identified [10].
To compare cross-sectional and longitudinal side-differences in thigh muscle anatomical cross-sectional areas (ACSAs), muscle strength, and specific strength (strength/ACSA), between knees with early radiographic change vs knees without radiographic knee osteoarthritis (RKOA), in the same person.
Objective: Whilst the characteristic pathologic feature of OA is the loss of hyaline cartilage, prior studies have demonstrated a poor relationship between severity of reported knee pain and degree of radiographic change.
The other patients also showed similar courses of radiographic change after treatment.
