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Argon beam coagulator is a monopolar coagulator which utilizes a beam of argon gas to deliver a radiofrequency electric current to the tissues.
Such a scheme has recently been reported using cisplatin-filled ultra-short carbon nanotubes that release their cargo upon exposure to high-intensity radiofrequency electric fields[19].
The use of a targeted thermal 'trigger' such as photon activation (i.e., NIR light) or radiofrequency electric fields could allow these SGSs to release their cargo into the cells upon irradiation by a stimuli.
Various hyperthermia techniques have been developed to treat breast cancer, including focused ultrasound [ 8], focused microwaves [ 9, 10], and radiofrequency electric fields [ 11].
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The use of noninvasive radiofrequency (RF) electric fields as an energy source for thermal activation of nanoparticles within cancer cells could be a valuable addition to the emerging field of nano-mediated cancer therapies.
High-intensity radiofrequency (RF) electric fields have the potential to overcome such barriers enhancing delivery and extravasation of chemotherapeutics.
We have recently found that high-intensity short-wave radiofrequency (RF) electric fields may reach regions inaccessible via conventional modes of generating tumor hyperthermia (Ware et al. 2015) and specifically affect tumor vasculature and dense tumor micro-regions to enhance the delivery and extravasation of chemotherapeutics.
For example, tumors that accumulate AuNPs can be ablated when the AuNPs are heated by radiofrequency (RF) electric fields or near-infrared photons so as to produce hyperthermic cytotoxicity in surrounding cells.
The aim of this study is to understand the combined and differential biokinetic effects of radiofrequency (RF) electric-field hyperthermia as an adjunctive therapy to [60]fullerene nanoparticle-based drug delivery systems in targeting the micro-vasculature and micro-environments of breast cancer tumors.
In radiofrequency ion traps, electric fields are produced by applying time-varying potentials between machined metal electrodes.
SLIM constitutes a novel class of ion optical devices, relying critically on a combined action of radiofrequency and DC electric fields and specific buffer gas density conditions.
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