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In the horizontal PET image, radioactive signals weakly spread over the whole brain.
Co-incubation with ANM082 or unlabeled MMPIP reduced the radioactive signals in the brain sections, respectively.
A method is presented to identify flow model parameters from radioactive signals with a high noise content.
To quantify expression levels, the radioactive signals and amounts of 28S rRNA were measured using computing laser densitometer ImageJ software (http://imagej.nih.gov/ij/), with radioactive signals being normalized by the amount of 28S rRNA.
The y-axis represents the detected radioactive signals (mV) and x-axis represents the RT in minutes.
The decrease rate of radioactive signals in each brain region was 34%to5353% for AMN082 treatment and 41% to 60% for unlabeled MMPIP treatment, respectively.
In the control section, strong radioactive signals were observed in the thalamus and medulla oblongata, followed by the striatum, middle peduncle, and cerebral cortex (Figure 3A).
By co-incubation with excess AMN082 (Figure 3B) or unlabeled MMPIP (Figure 3C), the radioactive signals in the brain section were homogeneously decreased, compared to the signals in the control section.
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The results were comparable to those seen in the monkey, with the radioactive signal peaking in the grey matter of the cortex within 6 to 15 minutes after injection, and then starting to decline steadily shortly afterwards.
Following the discovery of a particle with an unusual radioactive signal, the kit has been made more "sensitive".
The presence of blood contributes a background radioactive signal to the lung ROI, artificially increasing the measured signal.
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