Exact(1)
In phase I dose-escalation studies with the humanized IgG1 monoclonal CD44v6 antibody bivatuzumab, labeled with rhenium-186, the radiolabeled antibody showed promising anti-tumor effects with consistent stable disease at higher radioactive dose levels and with only low toxicity in patients with refractory head and neck SCC [ 42].
Similar(59)
Radioactivity uptake was expressed as a percentage of the injected radioactive dose per gram of tissue (% ID/g).
The radioactive dose was authenticated by a quality control analytical HPLC system.
The differences are in the radioactive dose, as PET imaging requires a higher dose than the biodistribution studies.
The difference may be due to the fact that radioactive dose administered to patients undergoing bone scintigraphy is different between Japan and Europe (mean dose, 740 vs 500 MBq).
The average injected radioactive dose was 306 ± 55 MBq.
The radioactive dose did not exceed 8 mCi (296 MBq) per scan.
The specific activity in the organs was calculated as percent of the injected radioactive dose per gram of tissue (%ID/g) after correction for radioactive decay.
The intensity of the obtained images was corrected by normalisation for the injected radioactive dose and body weight.
Uptakes are expressed as means ± SD of the percentage of injected radioactive dose per gram of tissue (% ID/g).
Therefore, toxicity to these organs limits the actual radioactive dose that is delivered to the patient by mAb carriers.
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