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The radioactive concentration there is reported to exceed 120 million curies – 2.5 times the amount of radiation released in Chernobyl.
As suggested by the images (Figure 2), a lower radioactive concentration led to a higher RMSE.
In particular, radioactive concentration has to be considered as a better indicator /criteria than the amount of radioactivity as such.
Regarding the accuracy of quantitative information, the best compromise was reached using TOF information and three iterations regardless of the radioactive concentration and lesion size.
SUV was calculated as follows: radioactive concentration in the region of interest (ROI) (MBq/g)/injected dose (MBq /patient body weight (g).
For the six HCC patients, high radioactive concentration in the tumors was detected using 90Y-PET, distinguishing tumors of different sizes.
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This resulted in substantial errors for radioactive concentrations of less than about 1 MBq mL−1.
For [11C]befloxatone in particular, in vivo studies in primates showed that, after pharmacological blockade, the residual radioactive concentrations were very low and identical in all brain structures [11].
PQ of dispensing systems might be carried out by performing at least three successful dispensing cycles in typical working conditions, i.e. using radioactive solutions of the intended activities and radioactive concentrations, dispensed in a representative number of vials / syringes.
In general, the change from one to three iterations substantially increased the noise in the reconstructed images and made visual detection difficult for radioactive concentrations below 3 MBq mL−1.
The current work was conducted in the context of a systemic injection when the radioactive concentrations are much smaller than SIRT, the ratio of lesion to background is, in theory, high and the signal from the natural radioactivity of 176Lu is of the same order of magnitude as that obtained for low concentrations of 90Y.
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