(B ) Sequence and secondary structure of a proof-of-concept RNA with one radical source attachment site (U13, in green).
As described in the main text, unsatisfied constraints could arise from structural perturbations due to radical source attachment, or conformational flexibility of the RNA, or the benzyl-thiourea linker tethering the radical source to the RNA backbone.
This expression simplifies in the limit of no background processes and low-oxidative damage rates (including radical-induced strand scission and nucleobase oxidation) (p i s, q j s ≪ 1, except at p i s = i = 1, corresponding to a reverse transcriptase stop at the site of radical source attachment).
A few weak signals in the proximity maps that were not predicted by the crystal structure (pink circles, Figure 1D) may be caused by perturbations of the ncRNA structure by radical source attachment or by conformational dynamics of the RNA or the ∼11 Å benzyl-thiourea linker tethering the radical source to the RNA backbone.
Rarely has the radical, romantic American attachment to the wilderness been explored with such sympathy and passion.
"The narrow view of love addiction is narrow, then, in the sense that it sees only extreme, radical brain processes, attachment behaviors, or manifestations of love as being potentially indicative of addiction and hence [love addiction] is thought to be quite rare," the analysis notes.
In 1867 he was denied a professorship at the Collège de France because of his attachment to radical scientific and political doctrines.
In this quintessential Zen expression are wedded together the meontological and psychological senses of wu/mu: a rejection of an ontology of independent substances, a declaration of an originary (self-negating) nothingness, and an expression of a radical freedom from egoistic attachment and freedom for spontaneous creativity and compassion.
Moreover, even below ~ 15 eV, LEEs can efficiently induce molecular fragmentation into highly reactive free radicals through dissociative electron attachment reactions (Boudaiffa et al. 2000).
This result may come from a very short lifetime of the photoexcited high spin states as a result of the attachment of radicals to TPS or from the very low efficiency of the intersystem crossing.
