I don't mean to imply that radical alterations to the text have been made.
The radical alterations to archipelago's geography caused by this cyclical coalescence and isolation of islands is likely to have complicated the evolutionary history of several iconic Galapagos species, notably the land iguanas, lava lizards, leaf-toed geckos and racer snakes.
The Chancellor welcomed Mr Carney's Toronto NGDP speech in December, but, along with the incoming Governor, the Treasury appears to have cooled on the idea of radical alterations to the Bank's mandate in recent weeks, despite the fact the economy contracted again in the final three months of last year.
Frequently, however, radical alterations to a gene's dosage are deleterious.
The evolution of parasitism from an ancestral free-living state can be accompanied by radical alterations to an organism's ontogeny, bodyplan, and life history (e.g., polyembryony in parasitoid wasps; [ 14]).
"He was the wrong man, in the wrong place at the wrong time," says Liam Sutcliffe, the man who made perhaps the most radical alteration ever to Dublin's skyline.
Major alterations included a radical change to overall treatment because of changes in diagnosis, disease stage or patient circumstance.
"If the Justice Department is widely staffed with junior ideological versions of John Ashcroft, that will represent a radical alteration and promises a return to the Reagan era," said Prof. David J. Garrow of the Emory University Law School in Atlanta, a longtime student of the Justice Department.
Centuries of mining and smelting activities, mostly without any environmental protection technologies, as we know them today, led to a radical alteration of (sub-) local pedogeochemistry with anomalies that may exceed local geogenic background values by several orders of magnitude[10].
