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A previous study has shown a dose dependent response after low-and high LET radiations in human mesenchymal stem cells [ 17].
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Recently, p14 was shown to affect p53 by additional mechanisms, including acetylations [74], response to ionizing radiation in human fibroblasts [75], and tumor-suppression following ionizing radiation in mice [76], [77].
CDKN1A/ p21 has been shown over-expressed after Fe particle radiation in human skin fibroblast and lens epithelial cells [ 29, 30].
Based on these data, we decided to further investigate the role of GATA3 in controlling response to low-dose radiation in human keratinocytes.
The ability of this screen to identify agents that enhance the effect of radiation in human cancer models has been validated in published proof-of-concept studies.
The effects and possible underlying mechanism of curcumin combined with radiation in human hepatocellular carcinoma (HCC) cells in vitro were evaluated.
In the present study, we attempted to examine the effects of varying doses of cobalt 60 radiation in human peripheral blood mononuclear cells.
Similarly, antioxidant protection against curative and palliative doses of ionizing radiation in human blood was reported to decrease with aging (Kasapovic et al., 2009).
Neutralising the antibodies against CD11b+ monocytes/macrophages given after irradiation markedly enhances the antitumour effect of radiation in human tumour xenografted mice (Ahn et al, 2010).
Altogether, these results suggest that Brachyury expression may attenuate cell cycle progression, enabling tumor cells to become less susceptible to chemotherapy and radiation in human carcinomas.
To better understand the influence of the EGFR blockade on radiation response in GBM, we investigated the antitumour effect of combined treatment with two mAb to EGFR and radiation in human tumour U87MG xenografts.
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