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MicroRNAs (miRNAs), a group of short non-coding RNAs that negatively regulate gene expression, have recently emerged as potential modulators of cellular response to ionizing radiations both in vitro and in vivo in various cell types and tissues.
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The most important recent observation is the detection of strong field aligned electric potentials at low and moderate altitudes in the auroral ionosphere that change our understanding of electric field acceleration and radiation both in the magnetosphere as well as in the shock ramp.
There are qualitative differences between high- and low-LET radiation both in the induction and repair of DNA damage (14, 16, 17).
Information on fluency distribution is necessary for estimation of radiation hazard both in the space (satellites, interplanetary missions, space stations) and in atmosphere (aircraft level).
The only safety concern for this project is its electromagnetic radiation, both in the visible and non-visible spectrum.
It is proposed to test the new detector in experiments with synchrotron radiation both in spectrometric and in current modes.
TZT-1027 also potentiated the induction of apoptosis in H460 cells by radiation both in vitro and in vivo.
This compound is known to sensitise mammalian cells to damage induced by ionizing radiation, both in vitro and in vivo.
Harada et al (2004) evaluated S-1 in combination with ionising radiation both in vivo and in vitro against human oral cancer cell lines.
The International Agency for Research on Cancer's Monographs on the Carcinogenic Risk to Humans also reviewed the effects of ionising radiation, both in the form of exposure to external γ or X-rays (IARC, 2000) and as α and β particles from internalised radionuclides (IARC, 2001), and all these types of radiation were classified as carcinogenic to humans.
Furthermore, we have recently shown that YM155 sensitised NSCLC cells to radiation both in vitro and in vivo, and that this effect of YM155 was likely attributable to the inhibition of DNA repair and enhancement of apoptosis that result from downregulation of survivin expression (Iwasa et al, 2008).
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