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Radiation quality control is a key component of the trial.
First is the radiation quality factor (Q), as defined by ICRP publication 60.
This allows estimating the radiation quality (photon energy) for the different dose values.
This manuscript discusses species sensitivity factors, tissue weighting factors, and radiation quality factors derived from relative biological effectiveness (RBE).
The severity of DNA damage depends on the physical characteristics of the radiation quality, e.g., the linear energy transfer (LET).
Further, the size distribution of DNA fragments showed a significant dependence on radiation quality, with an excess of fragments up to 1 Mbp.
Heavy ions are more efficient in producing complex-type chromosome exchanges than sparsely ionizing radiation, and this can potentially be used as a biomarker of radiation quality.
This has consequences for heavily ionising radiation protection procedures, which currently still assume a simple dependence of radiation quality on LET.
As underlined by several studies, the severity of the DNA damage depends on the linear energy transfer (LET) of the radiation quality [8 10].
For 131I exposure, ILK signalling was only statistically significant after 8.5 Gy, suggesting a difference in response due to radiation quality.
These measurements were made in mouse blood erythrocytes as a function of radiation dose, radiation quality, time after irradiation, and the genetic background of exposed individuals.
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