Exact(6)
Patients received 825 mg m−2 capecitabine b.i.d. on radiation days, except during the three boost fractions.
Capecitabine was given on all radiation days, thereby achieving a longer duration of interaction between radiosensitising chemotherapy and radiation.
The preoperative chemoradiotherapy with capecitabine 750 mg m−2 bid, concurrently during radiation (days 1 43) and weekly irinotecan 40 mg m−2 (six times) seems to be safe and effective.
In addition, by administering capecitabine on all radiation days, a longer duration of exposure to 5-FU and its cytotoxic metabolites during irradiation can be achieved, thereby potentially increasing the radiosensitising effect.
Our population reflects the treatment of AC in daily clinical practice, and we conclude that capecitabine 825 mg m−2 b.i.d. on radiation days can be used instead of continuous intravenous 5-FU in combination with MMC and IMRT in the treatment of locally advanced AC.
Neoadjuvant treatment consisted of 4,000 cGy of pelvic irradiation, five times a week, with a daily fraction of 200 cGy utilizing a four-field technique concomitantly with S1 on radiation days (a novel oral fluoropyrimidine inhibitory for dihydropyrimidine dehydrogenase with a potent radiosensitizing property).
Similar(54)
During the acute radiation response (days 1 7) food intake was reduced most markedly from days 2 5 with a nadir (60% reduction) between days 2 and 3.
Two thousand units of radiation a day for 35 days, with high doses of platinum chemotherapy, followed, a year later, by a dissection of the right side of my neck to remove the lymph nodes in which the cancer had reappeared.
In June, he began external beam radiation, five days a week, for a total of 33 sessions.
Mr. Katz chose high-dose external beam radiation five days a week for eight weeks at Columbia-Presbyterian Hospital.
Two months from now he will start external radiation five days a week for five weeks, and will continue hormone therapy as well.
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