Sentence examples for rac function from inspiring English sources

Dominant negative mutants of Rac have been the tool of choice in studying Rac function in cells.

As downstream mediators of Rac function, Paks have been implicated in regulating cell morphology, motility proliferation, and survival [17], [18], [19].

One possible interpretation of this finding is that Rac function might be important only during early steps in tumour progression, but not in later steps.

We reasoned that the developmental defects observed in the spleen and thymus of Rac1N/Rac3KO mutant mice was not attributable to a defect of endogenous Rac function in these organs.

Like other small GTPases, Rac GTPases function as molecular switches by cycling between GDP-bound inactive and GTP-bound active forms in cells.

Most of our knowledge on Rac protein function is based on work focused on the ubiquitously expressed Rac1.

In addition, the small GTPase Rac could function as a critical switch downstream of two types of innate immunity: PAMP-triggered immunity (PTI) and effector-triggered immunity (ETI) [ 66].

Furthermore, both p40(ABL/BCR) and p96 ABL/BCR) have also lost the Rac-GAP function of BCR, as shown by their incapacity to suppress Rac-activation in Rat-1 cells (Fig. 3).

A clue into such a pathway was shown in recent studies that tyrosine phosphorylation of ELMO (by Src family kinase) is required for Rac-GEF function.

Clostridium sordellii Lethal Toxin (LT) inhibits Ras, Rac, and Rap function, Clostridium difficile Toxin B abolishes Rac, Cdc42, and Rho function, and Botulinus C3 exoenzyme, in our study used as C2IN-C3 fusion toxin displaying high cell permeability [ 60], selectively inhibits Rho function [ 29, 30].

Consistent with this function Rac is mislocalised in loner mutants [29].