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To compare bone regeneration between local implantation of statin and low-intensity pulsed ultrasound (LIPUS), and the combination of statin with LIPUS in rabbit nasal bone using histological and immunohistochemical methods.
The purpose of this study was to investigate bone morphogenetic protein (BMP) 2 expression after implantation of a statin and recombinant human BMP-2 (rhBMP-2) and to compare the bone regeneration capability of these substances in the rabbit nasal bone using immunohistologic methods.
The decrease in TER may be due to an increase in paracellular permeability as seen in rabbit nasal epithelium [32].
The rabbit nasal ostium has previously been used as an experimental model (Asai et al. 2002; Marukawa et al. 2010; Lambert et al. 2010).
Huang and Donovan, 1996 studied transport of polystyrene nanoparticles (10 500 nm) across rabbit nasal respiratory epithelium and concluded that amine modified nanoparticles in the size range of up to 200 nm were transported via both paracellular and transcellular route [ 24].
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P. multocida was cultured back from all challenged rabbits nasal cavities.
Our use of low antigen doses may have contributed to the poor induction of mucosal IgA in rabbits after nasal immunization with Hcβtre immunogens since antigen dose has been demonstrated to influence the induction of mucosal IgA responses after nasal immunization [63].
In this study we evaluated our novel botulinum neurotoxin immunogens, Hcβtre and Hcβtre-Ad2F, for their ability to induce BoNT/A-neutralizing antibodies when nasally delivered to rabbits, a species whose nasal structure more closely resembles humans.
eliminated P. multocida from nearly all adult rabbits but in rabbits given enroflaxacin orally, although the nasal flush cultures were negative, the necropsy cultures from nasopharynx, cavity, tympanic cavity, and lung were all positive [ 17].
The nasal cavity of a rabbit is similar to the nasal cavity of humans and therefore the rabbit is a helpful animal model to optimize delivery of nasal vaccines.
To study the sedative and cardiorespiratory effects of transnasal (TN) administration of a combination of dexmedetomidine (DEX), midazolam (MID) and butorphanol (BUT) administered through a nasal catheter to rabbits undergoing diagnostic procedures.
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