Sentence examples for quite high dose from inspiring English sources

The combination of a fixed dose of doxorubicin 20 mg m−2 × 3 days with escalating doses of ifosfamide (1.2 2.75 g m−2 day−1 × 5 days) with G-CSF support in a phase I study focusing in stage IV chemotherapy-naïve breast cancer has yielded the feasibility of a quite high dose of ifosfamide 12.5 g m−2 (total) with an RR of 83% of which 33% were CRs (Bitran et al, 1995).

While the MTD reached for paclitaxel was 190 mg m−2 by 24-h infusion and for ifosfamide 3.0 g m−2 day−1 for 3 days (total dose: 9.0 g m−2), no major toxicities were en-countered with this quite high dose of ifosfamide administered by short noncontinuous daily infusion, while RRs in breast cancer patients were almost 62% with 31% CRs in this study (Bunnell et al, 1998).

The study did, however, have several limitations: the analysis was not intention to treat, studies of insufficient power were included, and quite high doses of PPI were in fact administered in the non-high-dose groups.

We elected to study chloroquine and omeprazole because they are in clinical use (for treatment of malaria and ulcer disease, respectively) and because quite high doses are tolerated in vivo (Lambers et al, 1984; Onyeji and Ogunbona, 2001).

As pointed out by Dr. Helzlsouer (20) in this issue of the Journal, many ongoing randomized controlled trials are now using quite high doses of vitamin D. As we await clearer evidence of benefits from those trials, we will also need to be prepared to be vigilant about their individual and collective power to assess any potential harms (21, 22).

Although 5 g/kg was quite a high dose in our experiment, 5 g/kg didn't present significant difference to 1 g/kg to the antitumor effect.

Borges is hoping epilepsy patients won't need quite such a high dose, however.

In Vietnam, HPV vaccines are not available on a routine use but women can order and pay for it at some preventive health care centers with quite high price (80$per dose x 3 doses).

Appropriate fluid loading preceding to the use of high catecholamine doses should be a main subject of discussion in patients with severe septic shock, because it is possible to wean quite a few septic shock patients from high dose catecholamines.

Alternatively, the effect of cimetidine might be unrelated to histamine receptors, especially because the effective dose (10 mM) is quite high.

Finally, the equivalent dose for 4DCT is quite high (29 40 mSv), about 4 times higher than that for 3DCT (3–10 mSv) [ 8].