The E-domain is a quite evolutionary-conserved region, especially for its COOH-terminal portion (~16 amino acids, see Additional file 3), supporting the finding that this region is of functional significance.
Obviously, there is quite an evolutionary gap between vervet monkeys and the Sumerians of 5000 B.C., the first people known to have drawn dragons.
Darwin did not supply a major set of new principles that could be used to derive general conclusions about life and its history: he crafted a framework within which his successors construct models of quite specific evolutionary phenomena.
Interestingly, these two proteins appear to have followed quite different evolutionary strategies in order to acquire novel functionalities, with OC following a gene duplication strategy while MGP variability was obtained mostly by the use of multiple promoters and alternative splicing, leading to proteins with additional functional characteristics and alternative gene regulatory pathways.
However, they have an additional pair of incisors in the upper jaw and the two orders have quite separate evolutionary histories.
Formerly respected and now quite worrisome evolutionary biologist Richard Dawkins has sung Condell's praises (again, according to his Wikipedia page, which is so self-aggrandising it's a wonder it can be attributed to such a staunch seeker of truths), saying that "Pat Condell is unique.
They belong to a quite different evolutionary lineage and can be quickly acquired or lost through transposition or recombination.
However, these studies imply quite different evolutionary scenarios for scleractinians, particularly in terms of relationships between suborders and families [8], [22].
Some proteins show quite strong evolutionary conservation of pI.
This was surprising, as it indicates quite some evolutionary distance.
Overall, the three hypervariable exon clusters appear to have experienced quite different evolutionary histories.
