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However its effect on mode II was quite deleterious, shown by scanning electron microscopy (SEM).
Drosophila cells contain only four chromosomes, and loss of one single chromosome might be quite deleterious.
For instance, only recently, we have found that depleting HDAC3 in post-mitotic neurons can be quite deleterious.
Several possible explanations for the lack of consistent benefit with intensive glucose management have been proposed, but the leading hypothesis is that it leads to a higher incidence of hypoglycemia, which is quite deleterious in AMI patients (14).
Similar(51)
When considering such problems, spurious numerical cavitation can be quite common and have deleterious consequences on the flow field stability, accuracy, etc.
In fact, assuming that all variants are deleterious works quite poorly, except for the step-up approach, which still did reasonably well.
Even at quite low levels (2.5 10 μg), deleterious effects of lead can be detected (Canfield et al. 2003).
Although the evidence for the frequency of slightly deleterious mutations is quite robust compared to that in other species, it is difficult to exclude categorically the possibility of lower mutation rates in nature than inferred from the laboratory.
Functional changes in such trans-regulatory elements therefore would often affect multiple processes in the cell, and are assumed to be highly deleterious and therefore quite rare (Stern 2000; Prud'homme et al. 2007; Peter and Davidson 2011).
Nevertheless, the mean sojourn times of newly arising neutral and deleterious mutations are quite similar (roughly 20% longer for neutral than for deleterious mutations) because a large fraction of both classes of mutations are lost soon after arising (fig. 4, middle panel).
It is quite likely that this perturbation is deleterious for binding and for efficient catalysis.
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