Exact(29)
Similar to leukemic stem cells, CD45+CD19- MCL cells also displayed a quiescent status as determined by dye efflux assays.
The quiescent status of cancer stem cells renders them difficult to eradicate with chemotherapy that typically target proliferating cells.
In adults, the quiescent status of HSC is believed to be a critical determinant in the ability of these cells to retain their full hematopoietic potential [36], [37].
As shown in figure 3, in vitro stretch quickly switched the uterine smooth muscle from relatively quiescent status to an active contractile state, characterized by a significant increase in amplitude.
Similarly, it may be appropriate to re-examine the assumption that the quiescent status of hematopoietic stem cells is a major obstacle to successful gammaretroviral vector mediated gene delivery to these cells [48], [49].
Collectively, the genes discussed above define a molecular signature associated with the steady-state quiescent status of HSC, and suggest common targets whose perturbation can lead to enhanced cell proliferation in the context of either differentiation, stem cell expansion, or transformation.
Similar(31)
In normal cells, depletion of paracrine growth factors reduces the activity of proliferation-stimulating signaling pathways and reduces basal cellular metabolism subsequently leading cells to enter a proliferation-quiescent status [ 12].
The duration of uveitis, disease status (quiescent or active), presence of macular edema, and anatomical location of the disease (intermediate, posterior, or pan-uveitis), among others, were collected.
First, regardless the gender and the quiescent or activated status of T cells, the GM and cholesterol content in cytosol and plasma membrane as well as the expression levels of GM synthase, Sphingomyelin phosphodiestarase 2 and HMG Co-A reductase genes involved in GM and cholesterol synthesis were constantly lower in CD4 thymocytes than in CD4 splenocytes.
Check the mE conditions to determine if the cell should enter the quiescent or death status.
On the other hand, regardless of the status (quiescent fast and slow twitch fibers, myotubes in transition or degenerating) the muscle cells exhibit plasma membrane p27 staining.
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