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Now receding towards the farthest point in its eccentric 75 year orbit, Halley was some 4,200 million km distant in 2003, when its frozen quiescent nucleus was last imaged as a faint smudge a billion times too dim to be seen with the naked eye.
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Further, the average stiffness of proliferating nuclei was significantly higher than that of quiescent nuclei (Fig. 2 C).
Germline transmission depends on a mutation of wls in the transcriptionally quiescent oocyte nucleus, whereas embryonic lethality arises from mutagenesis of the gene in the auxiliary nurse cells, which supply protein products to the egg through cytoplasmic bridges.
In "quiescent" fibroblasts the nucleus shows often angular profiles and reveals large amounts of heterochromatin condensations (Fig. 5), whereas in "activated" stages with increased matrix production the nucleus becomes enlarged, rounded and displays much more euchromatin (see below).
In quiescent crystallization, iPP nuclei are only formed in the beginning (and not in later stages) and grow simultaneously at the same rate, which leads to spherulites of equal size.
Intriguingly, a large amount of ZAP-70, both chimeric and endogenous, resides in the nucleus of quiescent and activated cells.
Following immunostaining, HMGB1 was found predominantly in the nucleus of quiescent HepG2 cells.
HMGB1 is abundantly expressed in hepatocytes, and predominantly localized in the nucleus of quiescent cells.
ASC is localized to the nucleus in quiescent cells, but it is recruited to the cytoplasm on cell activation [ 10].
Stb3 is restricted to the nucleus in quiescent cells and is immediately released into the cytoplasm after glucose repletion, whereas Tor/Sch9 inhibition causes its nuclear accumulation (Liko et al., 2010).
The use of high-melting fibres as linear nuclei for quiescent polymeric melts is instrumental in providing the superior mechanical properties of polymeric self-composites.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com