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In addition to showing that splenic lymphoid nodules express low levels of PrPC, the present study also showed that the lymphoid nodules possessed a sparse innervation, which questions the contribution of the large accumulation of PrPSc in splenic germinal centres to the process of neuroinvasion.
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The authors would like to acknowledge the families and individuals who patiently answered our questions, the contributions of the staff of the Indian Institute of Public Health, Gandhinagar, who were involved in the collection and management of data and the Alliance for Health Policy and Systems Research, WHO, Geneva, for financing the study.
It is also important to note that recent studies have questioned the contribution of monocytes in the maintenance of peritoneal macrophages in basal conditions (Yona et al., 2013).
Others have argued that these claims are premature [ 2]; indeed, some have questioned the contribution of genetic predisposition to the pathogenesis of common forms of type 2 diabetes [ 3].
GPs also seemed to question the contribution of dentists to the care of all patients at all times, with a perception that dental practices were run as small businesses, somewhat outside the NHS (box 3(3)).
Certain studies suggesting that loss of ATM may correlate with resistance to DNA-damaging chemotherapy and poor patient survival questioned the contribution of ATM in cellular response to anticancer therapies.
However, given that inclusions of poly(GP) proteins are present in some, but not all, affected regions of the central nervous system (CNS) in c9FTD/ALS [ 3, 20], and a recent study showing that poly GA) pathology, unlike TDP-43 pathology, does not correlate with the degree of neurodegeneration in c9FTD/ALS [ 40], put into question the contribution of c9RAN proteins to disease pathogenesis.
Outstanding questions include the contribution of glia such as microglia and astrocytes to pathogenesis as well as the impact of inflammation on neurologic outcomes in infants and children.
Thunnissen, Boselie, and Fruytier pose insightful questions about the contribution of talent management to the social and moral development of society and legitimating talent management at meso level.
In general, these results raise questions concerning the contribution of shifts in the mating system to the origin of the unique plant diversity of the Himalaya.
The guide also included questions exploring the contribution of the RC management strategies to the observed outcome: How can the link between the intervention and results be explained?
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