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A particularly interesting aspect of this contribution is that Kaplan argues that organizations charged with conducting international assessments must first prioritize causal questions in the development phase of the study.
We're asking similar questions in the development community, where electronic money services such as Kenya's M-PESA are making huge strides in reaching people who have not had access to formal financial services.
The leading theme for implementation has been to provide timely quantitative answers to critical questions in the development projects in order to enable decision-making.
More importantly, we believe the approach described here offers a strategy to address important questions in the development of blood-based cancer diagnostics that are not easily addressed in human studies alone.
Key questions in the development program were: (i) What is the comparative efficacy of tildrakizumab against it competitors?; (ii) What doses need to be studied in phase IIb to establish the full dose response curve?; (iii) What is the optimal dose and schedule to be used for phase III confirmatory trials?
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A critical question in the development of this new class of biomaterial is whether crosslinked conjugates have similar anti-inflammatory effects, which would open up a broad range of tissue engineering applications in which the material would have intrinsic inflammation-controlling function.
One critical question in the development of this new class of drugs is to determine the expression of the target in vivo.
In particular, Wnt-1, IGF-1, BMPs, ET-1, and PTHrP are some of the factors called into question in the development of osteoblastic metastases [ 47].
An important question in the development of decision aids about colon cancer (CRC) screening is whether to include an explicit discussion of the option of not being screened.
The manuscript by Schnermann and associates entitled, "Nephron filtration rate and proximal tubular fluid reabsorption in the Akita mouse model of type I diabetes mellitus" addresses a critical question in the development of diabetic nephropathy.
In this paper, we deal with a fundamental question in the development of multicellular organisms: How can biochemical reactions and genetic mechanism acting on the scale of minutes in individual cells generate dynamics with characteristic times of years to decades on the tissue level?
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