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Our study did have some weaknesses that must be acknowledged, including the retrospective design, the assessment of patient compliance was limited to direct questioning of study participants and one cannot be certain that all adverse events attributed to leflunomide were both drug related and caused by leflunomide (as opposed to one of the other DMARDs the patient was taking concurrently).
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This temporal disconnection allows for questioning of the relevance of localized studies to other grazed rangelands.
This has led to questioning of the physiological relevance of these in vitro studies [5].
Evaluation of the safety and tolerability of the study product was based on spontaneous reporting of adverse events by the subjects, as well as through nonleading questioning of the study subjects' general health at each study visit, or over the telephone on days 3 and 30 after retreatment at week 78 or at week 104 in those subjects who received retreatment.
The aims of this study were to: (i) design and implement strategies aiming to promote student questioning in the study of photosynthesis, and (ii) identify the strategies that lead to the formulation of a higher number of high level cognitive questions.
Senator Charles E. Grassley, Republican of Iowa, issued a statement questioning whether the study was part of an effort by the Food and Drug Administration to suppress the truth about the risks of antidepressants.
But Mr. Leedham is unenthusiastic about the idea, questioning the accuracy of studies put forward by the oil industry and Teamsters that the drilling would create more than 500,000 jobs.
After O'Bannon is done questioning the validity of studies published by one of the world's renowned scientific journals he can explain why 5 of 15 "fact sheets" on his organization's website offer no citations and 6 of the remaining 10 use the Guttmacher Institute, the very organization he claims has an "agenda", as a source.
There is merit in questioning the reproducibility of studies on marginal drug effects or sex differences, but it seems irresponsible to present, as Iorns and Chong have, a sweeping statement that 70% of all published peer-reviewed articles are irreproducible, even with the qualification of "surveyed" articles.
This, however, is not a view shared by researchers representing interests of biotech companies, who often participate in systematic opposition to any results questioning industry studies.
A semi-structured schedule of topics (see Appendix) was used to guide interviews, but this was not rigidly adhered to, and lines of questioning developed as the study progressed, initial data were discussed, and coding themes emerged.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com