ATRA has been investigated in breast cancer treatment with questionable results and toxicity [ 17, 18].
Question questionable sources.
In the present study, 0.1% atorvastatin in the diet was able to slightly reduce the weight gain of the mice and to induce elevated liver weights, indicating that the maximum tolerated dose of the drug has been chosen for the experiment and that results obtained with higher dosing would always be questionable due to unspecific toxicity of the compound.
However, due to their late onset of action (at least two hours), questionable efficacy, and possible toxicities such as colonic necrosis, cation exchange resins are not the recommended first-line therapy in acute hyperkalemia [ 9].
Because of its cumulative late toxicities and questionable impact on overall survival, up to now the role of radiotherapy remains undefined in advanced-stage Hodgkin lymphoma as well as in non-Hodgkin lymphoma.
While that's not much to go on, officials are already speculating that the 210 liter drum of booze was spiked with crocodile bile, locally feared as a potent poison whose actual toxicity is highly questionable.
Tacrine was progressively replaced by a new generation of acetylcholinesterase inhibitors, namely galantamine, donepezil, and rivastigmine, which were devoid of liver toxicity but produced questionable therapeutic benefits [ 2].
Considering that i.p. administration bypasses normal routes of exposure and results in rapid delivery into the blood stream, these results are of questionable relevance to the oral toxicity of Cr VI).
Thus, Ayurved Siriraj™ has removed ATC from its formulae since last year, although it is still questionable whether the formulae really cause toxicity.
When each of these questions cannot be answered in the affirmative, the animal ethics of conducting a WF toxicity study is at least questionable.
