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First, they omitted some data; second, they used unusual and highly questionable statistical procedures; and finally, yes, they made an Excel coding error.
Maintenance trials are based on questionable statistical designs but this approach may have an interest in certain subset of patients.
Unfortunately, the suggested methods depend on numerical solvers and only apply the constraint on the mean, giving questionable statistical properties.
However, the computational demands of these models have sometimes lead to the adoption of oversimplified assumptions, questionable statistical methods or a limited focus on small data sets.
Furthermore, the data on changes in gene expression when G9a-GLP complex components are depleted is weak and of questionable statistical significance.
In particular, the changes in target gene RNA levels caused by depleting components of the G9a-GLP complex are quite small and appear to be of questionable statistical significance.
Similar(53)
Furthermore, it is questionable whether statistical decision theory based on random sampling can be applied without further consideration.
Even if this basic difficulty is acknowledged, the validity of mappings may remain an issue due to questionable data sources, statistical and other methodological problems, and their visual representation.
For example, for safety data, it can be extremely important to conduct E-R analyses as part of the totality of evidence, either to support or challenge findings that appear unclear or questionable using classical statistical analyses.
Question questionable sources.
We did not observe differences between the hospital stay group and the same-day discharge group in terms of validated outcomes instruments at 3 months postoperatively, other than a small difference of borderline statistical and questionable clinical significance in terms of lower leg pain (< 1 point on a 10-point VAS, p = 0.05).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com