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It isn't that sadism can't be a laugh riot; it's just a question of modulation, of balancing the loud yuks and cruel jabs with some delicate feeling, mixing a real face in with the cartoons.
Indeed, in studies that have tackled the question of modulation of responses to agonists by the availability of G-proteins, data suggest modest shifts in dose-responses [27] [29].
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The question of whether modulation of these targets will be of therapeutic benefit in RA remains to be determined clinically.
The ongoing WHEL project (Pierce et al, 2004) tests the question of dietary modulation impact upon cancer preventive and treatment efficacy in a population of women with early-stage breast cancer (Pierce et al, 2004).
DOI: http://dx.doi.org/10.7554/eLife.06156.029 The experiments on HeLa cells and the theoretical analysis raise the question of whether modulation of early endosome homotypic fusion is a general mechanism to regulate signal amplitude and duration.
This review addresses the question of whether temperature modulation of chemical reactors can significantly affect reactor performance.
In this study we addressed the question of possible bidirectional modulation of cough response in human healthy volunteers by nasal challenges with TRPA1 and TRPM8 agonists respectively.
In this regard, recent findings place various miRNAs as unquestionable contributing factors in the pathogenesis of cardiac disorders, thus begging the question of whether miRNA modulation could become a novel strategy for clinical intervention.
But only a few studies have observed a decrease in H-reflex amplitude after exercise of multiple muscle groups as occurs for example in running (Avela et al. 1999; Bulbulian and Bowles 1992; Racinais et al. 2007b) raising the question of whether spinal modulation occurs after whole body exercise.
This raises the question whether modulation of the expression of the different subunits of the voltage-gated Na+ channels could have an impact on insulin secretion.
In the case of the inclusion of specific edges to define a 'modulation' then the question is what kind of modulation is this and how would one interpret or model such a vague concept and the mEPN equivalent of the 'stimulation' edge is an activation edge.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com