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It's all a question of dose.
A critical factor in P-450 induction in the clinic, based on the known drugs, is the question of dose size.
But the question of toxicology is a question of dose.
In all cases, the question of dose and distribution of BPs following a clinical administration is key.
16– 18 Our study was undertaken to address the question of dose distribution and SLNBa coverage according to TgF size.
Drug toxicity may simply be a question of dose, and a high dose will cause a pharmacological-type reaction.
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Ciresi et al.[ 12] studied metabolic parameters in GH-deficient children, but the question of dose-dependency was not investigated.
Finally, in addition to the question of dosing and timing (for example, bolus administration versus continuous intravenous infusion), the preferred route of H2S administration remains to be settled: while inhaling gaseous H2S probably allows easily titrating target blood concentrations, it is well established that this method can also directly cause airway irritation [ 76].
Finally, in addition to the question of dosing and timing (for example, bolus administration versus continuous intravenous infusion), the preferred route of H2S administration remains to be settled – that is, inhaling gaseous H2S versus intra-venous administration of injectable H2S preparations or H2S donors.
This pilot trial is investigating questions of dose and toxicity.
Most patients were treated with opioid medications before; consultations therefore mainly addressed questions of dose escalation or adaptation, a suitable choice of opioid, and management of breakthrough pain.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com