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van Schinkel et al (2013) addressed the question of cardiac toxicity of cisplatin-based chemotherapy with a quite novel method.
Given the standard of care for elderly, molecularly-unselected NSCLC patients has evolved to platinum doublet, as well as the significant question of cardiac toxicity, further development of this regimen does not appear justified.
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The existence of these two cardiac progenitor 'fields' raises the question of when cardiac precursors are allocated to these populations and their contributions to mature structures in the heart, such as the IVS.
However, the question of whether cardiac surgery with CPB influences the perioperative balance between pro- and anti-thrombotic activity in children with complex cardiac defects has not been addressed so far.
The authors address a long-standing question of how cardiac progenitors get added to the developing heart, which expands rapidly but without very much cell division once differentiated.
Another important avenue of research in the future is to answer the question of whether cardiac and skeletal muscle pathologies that are associated with Popdc-null mutations in animal models are also found in patients.
This observation raises the question of whether cardiac toxicity might also be increased by adding EPA or DHA to anthracyclines, but this does not appear to be the case at least in rats [ 74].
There were three portions to the DIAD study; the first described the prevalence and predictors of silent ischemia, the second identified which factors were associated with progression and which with regression of CAD, and the third addressing the question of whether cardiac event rates were affected by screening versus not screening among individuals with type 2 diabetes.
Interestingly, other groups have also questioned the dependence of cardiac Smad signalling on TGF-β [ 57, 58].
The question of whether the cardiac visceral adipose tissues (EAT and MAT) and SAT have similar 11β-HSD-1 and glucocorticoid receptor (GCR) gene expression patterns in obese patient with CAD (obese CAD group) and non-CAD (controls) has not been addressed before.
Clinically relevant questions in the field of cardiac 18F-FDG PET, e.g. to accurately define the amount of tissue still metabolically active in or around a lesioned site, could benefit from anatomy-based PVC.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com