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However, the recent QUEST study [48] suggests that ToF-PET scanners are likely to improve contrast of hot spheres and increase RCs.
Our study performed an extra scan at a lower activity level (0.3 GBq) that was not performed in the PET/CT QUEST study.
These values are consistent with those reported in the QUEST study for both the Siemens Biograph TOF (> 1 iteration, no post-reconstruction filter reconstructions only) and non-TOF PET/CT (PROMPTS+RANDOMS reconstructions only) scanners [20].
The results from this study and that reported by Willowson et al. in the PET/CT QUEST study [20] also demonstrate the feasibility of performing multi-institutional clinical studies focused on 90Y PET-based dosimetry.
Our study mirrors the work that was performed by Willowson et al. in the QUEST study but, due to the difference in scanner designs and electronics, focuses instead on PET/MRI scanners.
Since our RCs agreed well with those reported in the QUEST study by Willowson et al. for Siemens Biograph TOF PET/CT scanners, we consider this effect to be negligible.
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