He goes on a quest for the missing Rema, a quest that takes him to Patagonia.
Curiously, like the famous journey that began his exploring career, this final trip was a quest for a missing white physician.
This remarkable creature, named Dinka, leads Assaf on a picaresque quest for the missing Tamar, and in so doing embroils him in Tamar's personal dramas.
Isabel herself remains more of a symbol than a person, and in the end her quest for her missing brother, too, feels less like a real search than a sort of Jungian hunt for a missing part of herself.
The quest for the missing father through clues and contacts, in London, Geneva and Cairo, has the feel of one of Brian Moore's later books – The Statement, or Lies of Silence – where character and depth are streamlined into taut, fast thriller mode.
Not an excuse that film-maker George Sluizer can use, however, as he reworked his peerless Dutch thriller Spoorloos, about a man's obsessive quest for his missing girlfriend and the cat-and-mouse game played with her abductor, into one of the worst remakes of all time.
It keeps the premise of writer Harry Mason's quest for his missing daughter after a car crash, although it leads into a different plot.
"So, while Malala enjoys support in the West for her cause, Nabila has managed to secure an overwhelming amount of support from the people of Pakistan," wrote Hina Baloch, "Farzana, the sister in quest for her missing brother, remains as lonesome as ever.
Clearly, in this quest for the missing heritability high-throughput-sequencing (HTS) technologies play a pivotal role.
New high-throughput, population-based methods and next-generation sequencing capabilities hold great promise in the quest for common and rare variant discovery and in the search for "missing heritability".
