Information about the quantity of administration, the number of weeks the subjects worked on the programme, was gathered with the use of log forms for the parents to be filled in every day.
Because the control on treatment integrity in the Dutch intervention study (van Otterloo et al., 2009) was only based on self-report, monitoring and checking the quality and quantity of administration more precisely might stimulate better treatment integrity, which might lead to larger training effects.
Although a reduction of administration of gemcitabine was needed in two-thirds of the patients in this study because of grade 3 or 4 neutropenia, it was possible to limit grade 3 or 4 neutropenia during all cycles to 18% by reducing the quantity of administration of gemcitabine in subsequent cycles.
Less than 10% described either dose quantity, frequency of administration, or duration of the course of therapy, and a similar proportion described route of administration.
But the results show that it is important for protocol feasibility studies and patient recruitment tooling to be able to ascertain the basic timing of the course of therapy (i.e., start and stop dates), even if the detail of the dose quantity, frequency of administration, or route of administration within that course is not provided in any machine readable/queryable way.
Two aspects of treatment integrity were assessed: the quality and the quantity of the administration of the intervention programme.
Furthermore, most of the protection from AKI seemed to occur in studies reporting equivalent total quantity of fluid administration between groups.
" Dosage instructions information [ 14] is information about dose quantity (individual dose quantity, daily dose quantity, or cumulative ("lifetime") dose quantity), about timing of administration (frequency of individual administrations or duration of the course of therapy or start/stop dates) and about route of administration.
The quantity of insulin released by β-cells fluctuates and changes according to the quantity, nature, and route of administration of the stimulus.
Electronic prescriptions issued by the GPs are also recorded, including prescription date, formulation, strength, quantity prescribed, and route of administration.
Prescriber information, defined daily doses (DDD), strength, quantity, method and unit of administration of each drug dispensed, net ingredient cost and pharmacist dispensing fee per item dispensed are also available.
