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TaqMAMA combines the quantitative strengths of TaqMan with the allele-specific PCR of MAMA.
Mixed methods are not intended to replace, but instead draw from qualitative and quantitative strengths while minimizing their limitations to offer a more pragmatic and pluralistic mode of inquiry [ 21- 23], including end-of-life research [ 24].
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Included within the last are quantitative strength, dose response relation, and study design.
A priori, the intent of the analysis was to indicate the overall direction of current evidence for each of the prognostic factors in a qualitative manner with no report on quantitative strength of effects.
Recently, it was understood that quantitative (strength and duration of activities of the pathways) rather than qualitative (e.g. regulation of different pathways) differences between signaling pathways may largely account for dissimilar biological responses [11].
Therefore these quantitative strength measurements relative to the normal population highlight the strength deficit of these patients in a quantitative way.
In contrast, we determined that all of the subunits give the same quantitative strength of interaction and cluster together in their phenotypic gene interaction profiles across several chemical perturbations.
Examples are the calculation of influences which represent the quantitative strength of interaction between certain genes [ 3], or the determination of steady-state distributions to quantitatively predict the activity of certain genes in steady state [ 8].
These patients had been followed in the outpatient clinic of the NIH Clinical Centre with serial quantitative strength measurements every 6 months for up to 12 18 months, prior to enrolment in the CAMPATH study.
We have tried to avoid the pitfalls of unconvincing and unsubstantiated qualitative data by ensuring the quantitative strength of our themes was measured, but also recognised that in this kind of research, simple counting of themes is not necessarily reflective of the qualitative strength of a theme, which is presented in the more detailed qualitative description.
In addition to qualitative categories of histone methylation, we examined quantitative "strength" of methylation as represented by the number of ChIP-seq tags within 1 Kb distance from TSS for H3K4me3 and 3 Kb distance from TSS for H3K27me3 based on data from [ 7].
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