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Identifying these relationships would provide quantitative rationale for prosthetic foot prescription that may lead to improved amputee gait.
Model-based simulations provided a quantitative rationale for dose selection in phase 3.
In conclusion, findings from pharmacometric analyses provided a quantitative rationale for dose selection of 25 and 50 mg q.d.
Furthermore, the main objective of the present analysis was to provide a quantitative rationale for selection of doses for phase 3 trial using two pharmacometric approaches.
Furthermore, this extended consideration of allostery, where intrinsic disorder can maximize the ability to allosterically couple two sites, provides logical explanation and a general quantitative rationale for the high prevalence of disorder in various regulatory proteins, such as transcription factors.
doses for 12 weeks, (iii) project and compare HbA1c response with dipeptidyl peptidase 4 (DPP-4) inhibitors and TAK-875 up to 24 weeks, and (iv) provide a quantitative rationale for dose selection in phase 3. On the basis of phase 2 data, relationships between TAK-875 concentrations and HbA1c were well characterized by exposure response models.
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Our results provide a basis for quantitative rationales behind HER2 diagnostic guidelines that call for increased numbers of evaluated cells and emphasize the importance of well-designed data analysis methods in diagnostic pathology, especially for predictive clinical application.
Risk assessments such as ours can provide quantitative prioritization rationale for efforts intended to mitigate the impacts of synanthropic species on threatened species.
Strobe 11: Please explain the rationale for quantitative outcome cut points and whether or not they were previously specified.
We have advanced the rationale for quantitative risk assessment in chemoprevention trials, with the advantages of improved power using a smaller study population, shorter study duration and lower cost [ 63].
The two proposed conditions and rationale offer a quantitative basis for developing "good practice" guidelines for SRS of complex turbulent wake flows with coherent structures.
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