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The second idea suggests using results from analyses of heterogeneous two-cell networks to constrain larger network dynamics since quantitative linkages occur between two-cell and N-cell network dynamics.
To the extent possible, quantitative linkages between environmental data and personal exposure measurements should be established as a basis for developing predictive models for exposure assessment.
The quantitative linkages observed in this experiment are unlikely to hold for an in vivo system but suggest that an experiment exposing laboratory animals to TCDD, which includes both TCDD and RA measurements with gene expression measurements, would be useful.
With butadiene and related compounds, the ultimate challenge is to identify useful biomarkers of exposure in which quantitative linkages between exposure and internal dose of the important DNA-reactive metabolites are established.
A recent example of how a toxicity pathway approach can be used to establish quantitative linkages across biological levels of organization was provided by Miller et al. (2007) and Ankley et al. (2008a), who investigated the consequences of molecular changes in the fish hypothalamic pituitary gonadal (HPG) axis in terms of reproductive and population effects.
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This finding provided a useful quantitative linkage between the colloidal fouling potential and the water chemistry.
However, quantitative linkage between solubility behavior in chemically simple melts and more complex natural magma compositions await detailed structural characterization of the water solution mechanisms in simple and complex magmatic melts.
A linear regression model of the log-transformed VEGF on age was applied and the residuals were used as a quantitative trait in the multipoint quantitative linkage analysis on each sub-pedigree set using the regression-based approach implemented in MERLIN-REGRESS [27].
The strength of the response is in quantitative linkage with the number of hERα binding sites along target transcripts.
Descriptive linkage was the most common, whereby both animal and human health outcomes were presented, but without quantitative linkage between the two.
Classical and quantitative linkage analyses of genetic crosses have traditionally been used to map genes of interest, such as those conferring chloroquine or quinine resistance in malaria parasites.
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