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Family-based association tests (FBAT), including quantitative disequilibrium tests (QTDT), were done using FBAT v1.5.5.
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Δ, mean difference between the allele carriers and other individuals in age at onset of the disorder; EOT = extreme offspring design t-test; FBAT, family-based association test; Freq., frequency; n inf., number of informative families for TDT in the sample; QTDT = quantitative transmission disequilibrium test; TDT = transmission disequilibrium test.
Additionally, quantitative transmission disequilibrium test (QTDT) [13] was performed to further examine the association between the tagging mutations and adjusted obesity-related phenotype data.
Two statistical approaches the general linear model (GLM) and the quantitative transmission disequilibrium test (QTDT) were used to detect associations between genetic polymorphisms in both bovine UCN3 and CRHR2 genes with IMCL and SFD in a reference population of Wagyu×Limousin F2 cross cattle (Table 1).
We used the quantitative pedigree disequilibrium test (QPDT) [ 41] implemented in UNPHASED [ 42].
The quantitative transmission disequilibrium test (QTDT) (Abecasis et al. 2000) implemented in the genetic analysis package SOLAR.
Two-marker (UCP1 and UCP2) and three-marker (UCP1 only) haplotypic associations were evaluated in each population separately using quantitative pedigree disequilibrium tests (QPDT) [ 31].
UCP: uncoupling protein; AIRg: acute insulin response to glucose; QPDT: quantitative pedigree disequilibrium test; HWE: Hardy Weinberg equilibrium The author(s) declare that they have no competing interests.
Tests of allelic association were performed using the Quantitative Transmission Disequilibrium Test (QTDT) [ 20] on ADHD scores residualised for sex effects.
We observed a significant association of DAOA variants rs3916966 and rs2391191 with visuospatial ability (Quantitative Transmission Disequilibrium Test [QTDT]; p = 4 × 10−6 and 5 × 10−6, respectively) (n = 159) with the two variants in almost complete linkage disequilibrium.
We used the Quantitative Transmission Disequilibrium Test (QTDT) software package (15) with the polygenic variance component option and performed association analyses of quantitative traits with the total association model assuming no population stratification.
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