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In the future, quantification will be of growing importance especially in multicenter clinical trials, and therefore, standardized calibration procedures need to become applied widely.
In that case, one could still acquire 'enough counts', but these are then of little value since image quality will be poor, and quantification will be inadequate.
Strategies to address the key design challenges of sensitivity, selectivity, in vivo compatibility, and quantification will be discussed using examples of recently developed molecular scaffolds for selective H2S detection.
In the next section, where various applications of plural quantification will be discussed, I will carefully note which strains of the notion of logicality our theories PFO and PFO+ must possess for the various applications of them to succeed.
In particular, second-order logic and the theory of plural quantification will be each closely related to two first-order two-sorted theories, which lack the expressive resources often attributed to each extension of classical quantificational logic.
What really matters is presumably whether we can iterate the principles and considerations on which our understanding of ordinary first-level plural quantification is based: if we can, then higher-level plural quantification will be justified in much the same way as ordinary first-level plural quantification; and if not, then not.
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Nevertheless, improvements in temporal and spatial resolution, paired with the ability to make precise quantifications, will be necessary to connect observations and theory.
If the pre-existing immunity is imperfect and described by the so-called leaky protection (e.g. partial reductions in susceptibility per contact and in infectiousness upon infection), those quantifications will be required in addition to the estimation of the proportion of the initially immune population.
Mass-spec and RT-PCR quantifications will be robust by the consistency of the assay material.
A spokesperson for the HFEA said: "Our Scientific and Clinical Advances Advisory Committee is considering data that has been presented to it in relation to mitochondrial DNA quantification, and will be publishing its advice in due course".
Developing the device further, the described quantification procedure will be transferred onto the point-of-care device to enable testing of patient-derived samples in the future.
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