All the 17 selected analytes were semi-quantified using a different analyte to assess the quantification performance under various conditions.
In the numerical verification, the damage quantification performance of the proposed method is compared with the performance of other existing methods.
Although reconstruction algorithms suitable for bremsstrahlung imaging of 90Y are under development [9, 10], the resulting images have the disadvantage of having a low spatial resolution and poor quantification performance, especially for small lesions when using parallel-hole collimators.
To improve the damage quantification performance, the methodology is derived by eliminating erroneous assumptions in the existing modeshape-based methods and adopting additional modal information, i.e., natural frequencies.
Our initial dataset used to evaluate quantification performance is comprised of samples from the prostate cancer cell lines DU145, RWPE, VCaP, and LnCaP, and one prostate cancer tumor tissue with a matched adjacent normal sample.
We also investigated the effect of multi-mapper handling on the quantification performance (Fig. 4B).
Recent MS instrument development has improved the quantification performance of high-resolution MS devices.
The very good quantification performance of the protocols on FFPE samples is of significant impact for researchers with clinical samples.
Moreover, 2-DE shows poor quantification performance for proteins with particular features such as extreme sizes (large or small), large hydrophobicity, low abundance or extreme isoelectric point.
Based on our observations, we then introduce a hybrid approach in the analysis of sequencing reads, for which we can demonstrate substantially improved quantification performance.
