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Quantification of chemicals in biota is often analytically challenging.
The identification and quantification of chemicals play a vital role in evaluation and surveillance of environmental health and safety.
To address this problem, it was previously suggested to use microbial biosensors to facilitate the detection and quantification of chemicals of interest.
Major challenges to mass balances are the collection of representative samples and accurate quantification of chemicals in sludge.
Most of the assays are based on the quantification of chemicals, their metabolites, or reaction products in blood and urine samples.
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This method greatly facilitates the quantification of chemical markers in complex matrixes with only a small amount of sample.
Localized, or MRI-guided, MR spectroscopy enables quantification of chemical composition of different tissue components in small volumes of less than 0.1 ml.
Magnetic resonance spectroscopy (MRS) allows the detection and quantification of chemical compounds from localized portions of the living tissue, e.g., the brain, in a noninvasive fashion.
Raman spectroscopy has potential for non-invasive detection and quantification of chemical solids concealed within packages e.g. plastic bottles, bags or blister packs.
While Raman spectroscopy is sensitive and non-destructive, its validity towards precise quantification of chemical charge doping has not been tested.
The STXM enables the quantification of chemical compositions of the submicron-sized samples as well as elemental/molecular mapping with high spatial resolution (<30 nm) (Kilcoyne et al. [2003]).
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