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For accurate quantification of activities, experimental samples were counted for 1 min. on a calibrated Perkin Elmer (Waltham, MA) Automatic Wizard2 Gamma Counter by using an energy window of 800 1000 keV for 89Zr (909 keV emission).
For accurate quantification of activities, experimental samples were counted for 1 min on a calibrated Perkin-Elmer (Waltham, MA) Automatic Wizard Gamma Counter.
DOI: http://dx.doi.org/10.7554/eLife.00312.005 10.7554/eLiFigure1 figureigure 1—figure supplement 3. Quantification of activities and FOS intensity in mice exposed to an enriched environment during the dox-off window.
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In the present work, we focused on quantification of activity of 3,4,6-substituted-2-quinolone 3,4,6-substituted-2-quinolone 3,4,6-substituted-2-quinolone 3,4,6-substituted-2-quinolone
The accuracy of the quantification of activity concentration depends on a number of factors in addition to the segmentation of the image.
The body attenuates the majority of the emitted 511-keV photons and attenuation correction (AC) is therefore essential for accurate quantification of activity concentrations [8].
Absolute quantification of activity concentration was compared after bolus passage during steady state, i.e., between 2.5- and 5-min post injection.
However, in case of a small-animal study where quantification is (all- important, speciall- importantuspecialattentionl checks, and if necessary, adjustmusts, which are directly related to quantification of activity concentrations in the images.
In order to achieve such personalized dose assessment, the accurate quantification of activity within organs of interest (critical organs) and tumors must be performed and temporal changes of this activity determined.
Since quantification of activity for dosimetry purposes is done using images reconstructed from primary photons (PP) recorded in the photopeak window(s), the deadtime correction method must correct for count losses that affect only these primary photopeak photons.
This is an important conclusion, as the exact quantification of activity in an organ is crucial for the accuracy of dosimetry calculation for this organ and such dosimetry is particularly important for critical organs, such as, for example, the kidneys.
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