Capacity building for sophisticated drug quality testing facilities as part of an integrated drug quality surveillance system is necessary.
A good quality surveillance system with laboratory support is essential for understanding the causes of AES and responding appropriately.
To prevent the production of unfolded proteins, cells induce the unfolded protein response (UPR), which is a highly regulated protein quality surveillance system.
Our results indicate that Rsp5 and the ART adaptor network function as part of a PM quality surveillance system, detecting integral membrane proteins at the cell surface as they become conformationally unstable and targeting their internalization and degradation.
Investment must include improving technical capacity so that drug quality analysis can be conducted using reliable and accurate methods such as HPLC and dissolution testing to be a part of an integrated drug quality surveillance system.
The discovery of substandard antimalarials and the availability of drugs that are outside of national policy and guidelines warrant an effective drug quality surveillance system and more stringent antimalarial drug regulation in Afghanistan.
