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Molecular measures are needed that define the quantity and quality of responsiveness to adjust the dosage or change the drug.
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For example, quality of alert responsiveness is designed to measure "processing" alertness, not just simple awake, eyes-open states.
Reliability was assessed using intraclass correlation coefficients in subjects reporting no change in global quality of life; responsiveness was assessed using effect size and Guyatt coefficients in subjects reporting change in global quality of life.
The NBAS supplementary items analyzed (quality of alert responsiveness, cost of attention) were designed to capture qualitative aspects of the infant's ability to attend to visual and auditory stimuli.
For example, the decrement in quality of alert responsiveness score was −0.51 (95% confidence interval, −0.99 to −0.03) for the highest quartile of exposure to the sum of four prevalent PCB congeners compared with the lowest quartile.
Factor analysis was used to systematically group the PS-13 questionnaire into three factors of technical quality of care, responsiveness to patient preference, and management of patient preference satisfaction subscales.
Our results show consistent inverse associations between PCB, TEQ, and DDE cord serum levels and attention-related NBAS outcomes, including alertness, quality of alert responsiveness, and cost of attention.
For the 542 subjects with an NBAS exam at 2 weeks, we observed consistent inverse associations between cord serum PCB and DDE levels and NBAS measures of alertness, quality of alert responsiveness, cost of attention, and other potential attention-associated measures including self-quieting and motor maturity.
Individual NBAS items fell into three broad domains: a) measures of attention (alertness, quality of alert responsiveness and cost of attention), b) measures of state (consolability, self-quieting activity, hand-to-mouth facility, irritability and never in state to do orientation items), and c) measures of motor function (elicited and spontaneous activity, and motor maturity).
Thus, it has been suggested that for measures of physical function and quality of life, responsiveness should be based on the subject's perception of meaningful change but that for measures of impairment or disease activity, the physician may provide the best judgment [ 21].
Two supplementary items measuring alertness were selected for inclusion in the analysis: a) quality of alert responsiveness, which assesses the level of "processing" alertness as opposed to a simple awake "eyes open" state, and b) cost of attention, which measures the degree to which the motor and physiologic systems were stressed as a result of the infant's efforts to attend to the stimuli.
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