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Nowadays, though, I'm spoiled for choice, and the quality of formulations is increasing year on year.
Results of the experimental design helped to determine significant variables influencing the quality of formulations.
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From the clinical perspective, considerations include maintenance of an appropriate medication dose during the switching process; drug equivalence in terms of clinical effectiveness; and safety issues, including the diverse adverse-event profiles of available alternative drugs, differences in the 'inactive' components of drug formulations and the quality of generic formulations.
The discrepant results achieved for pain control or structural improvement in osteoarthritis patients has been attributed to the quality of chemical formulations or different bias in clinical studies.
Inoculant improvement has been associated to more effective methods to evaluate the quality of bacterial formulations (inoculants) (Tong and Sadowsky, 1994), as well as those related with the isolation, identification and enumeration of bacteria in carriers, seeds, soil and plants.
Additionally quality of the formulations may suffer as a result of being transported and stored inappropriately.
If the decomposition products of ARTs [21], were to react with both chemicals, and then separating the components with migration on TLC will serve to indicate the quality of the formulations.
Microbiological quality of the formulations was assessed according to the methods recommended by Pinto et al. [ 28] in order to avoid further contamination of the formulations.
Quality of the formulations of sulfadoxine/pyrimethamine, quinine, and chloroquine (N = 37) was determined using the in vitro dissolution testing protocols as detailed in the drug monographs outlined in USP 24.
Rational use of drugs backed by properly enforced regulations and measures to assist clinical decisions and guarantee the quality of drug formulations may forestall the generation of resistance to new drugs [ 174].
Of 37 samples (chloroquine N = 25; sulfadoxine/pyrimethamine N = 9; quinine N = 3) tested using the dissolution analysis to determine the quality of the formulations, 12 (32%; N = 9 sulfadoxine/pyrimethamine and quinine N = 3) did not meet the set USP tolerance limits and were therefore of poor quality.
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