Drug-resistant TB is associated with inadequate treatment, resulting from too few or low-quality drugs, non-compliance on part of the patient, and conditions which favour TB transmission.
Some manufacturers question the need for GMP when their products sell well and there is no evidence to show that the GMP certificate guarantees high quality and GMP non-compliance results in low quality end products.
Similar to observations in other areas of medicine, the factors of cost, convenience and side effects of pharmacotherapies can influence a patient's lifestyle, quality of life, non-compliance with medication regimens, and ultimately, their clinical effectiveness [ 11- 13, 48, 49].
High numbers of environmental coliforms undermine the validity of routine sampling programs and often lower annual water quality results into the non-compliance categories.
Process variations can include a defective cleaning system that does not fully remove process contaminations, such as fingerprints, or similar non-compliance with quality assurance measures.
Direct observations according to the 'My five moments for hand hygiene' approach still provide important additional information on non-compliance and quality of hand hygiene.
Non-compliance with quality criteria or with social obligations must be recognised as providing grounds for exceptional termination of a contract.
However, non-serious reactions can also be extremely troublesome, above all when they are chronic: they can affect patients' quality of life and contribute to non-compliance.
Also, the European Commission proposal for a regulation of compensation, in cases of non-compliance with contractual quality requirements for rail freight services, eventually led, in 2003, to the industry-led UIC/CER/CIT Freight Quality Charter [9].
Nevertheless, this device is not able to record non-compliance and the quality of hand disinfection.
The indicator does not take into account disease incidence or prevalence or whether deaths occur due to shortcomings in access and quality of care or avoidance and non-compliance on part of the patient.
