Your English writing platform
Discover LudwigExact(1)
We selected 15 cell lines from the NCI60 panel [ 8] for which high quality mutation data are made available through the cosmic database [ 9] for a large list of known cancer genes.
Similar(59)
In short, our approach is based on intercepting database accesses and applying typical data quality mutations to the data being delivered to the application.
For each sample from Complete genomics, low quality mutations (FT = VqLow) and/or mutations with allelic depth ≤ 2 were discarded.
In addition, BRCA1 and BRCA2 capture probes are included on the panel, which enable high-quality mutation screening for deleterious variants in these genes in the same assay.
In total, we identified 107,122 single-nucleotide polymorphisms (SNPs) from the exome of the proband (Table 2) by using SOAPsnp based on Bayes' theorem, by filtering out low-quality mutations according to the criteria (reads < 20, depths < 4, estimated copy number > 2 and the interval in between < 5).
In order to alleviate such difficulties and improve solution quality, the mutation operator is adopted from the genetic algorithm.
In contrast with this prediction, we found that female preference was often negatively correlated with male somatic quality when mutation probability increased with male age.
No correlation could be established between surgical resection quality and mutation rate.
The history of in situ testing for HER2 should encourage physicians and health authorities to pay attention to the quality of mutation testing in cancers.
We used three parameters to assess quality: BRAF mutation status, response times and conformity to the French recommendations for test reporting.
DNA of suitable quality for mutation analysis was obtained in only 10 cases, mainly because of improper fixation of paraffin-embedded tissues.
Write better and faster with AI suggestions while staying true to your unique style.
Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com