The convergence quality is checked by using 32 beads, which do not change the results substantially.
Solution quality is checked against pre-defined tolerances assigned to the geometry constraints.
Data quality is checked by calculating Spearman correlation between biological replicate signatures.
Data quality is checked on a regular basis for each hospital based on random samples of documentation, and extensive plausibility checks were conducted before data analysis.
Data quality is checked by evaluating inter- and intra-laboratory reproducibility of biological replicates by clustering, Spearman correlation and determining the overlap in lists of differentially expressed genes (Noriyuki et al. 2012).
Accuracy and reliability of Pb determination were checked by national evaluation of quality control: The quality is checked every 3 months by determining the level of Pb in samples sent to the Agence Française de Sécurité des Médicaments (French Agency for Drugs Safety).
