Sentence examples for quality control machineries from inspiring English sources
Moreover, when using eukaryotic expression hosts, intrinsic quality control machineries for proper protein folding and stability exist that allow for co-selection of high-level expression and stability simultaneously to the binding functionality.
Indeed, in such a situation the ubiquitin proteasome system and the cellular quality control machineries may be overwhelmed or inhibited by both Sup35p and CFTR aggregates [69].
Since Malectin is a stress-responsive gene, it is conceivable that Malectin-regulated inhibitiof of cargo export is activated under conditions of ER stress, possibly to avoid that defective gene products are secreted under condition of aberrant functioning of the ER quality control machineries.
Thus, our findings expand the roles of AMPK in protein metabolism beyond mTORC1-mediated translational control and reveal that by gauging cellular energy status, AMPK finely orchestrates protein quantity and quality control machineries.
Significantly, most of the LIN Es in the human genome are located in AT-rich regions of the chromosomes, far from genes, and therefore far from the DNA quality control machinery that attend to the genes'swell-being and mighthery to sniff thumanut and eliminate them.
The mitochondrial quality control machinery is affected in aging and especially in PD, thus affecting intraneuronal protein transport and degradation, which are primarily responsible for accumulation of misfolded proteins and mitochondrial damage in sporadic as well as familial PD.
As such, care needs to be taken to avoid further saturating the quality control machinery.
Remarkably, these signals are interpreted by the quality control machinery to use the ERAD pathway under normal conditions.
Misfolded proteins are generally recognised by cellular quality control machinery, which typically results in their ubiquitination and degradation.
Misfolded proteins that were destined for lysosomes accumulate in the ER, and these are rapidly degraded by the cellular quality control machinery [45].
Therefore, at least in the two investigated mutants, there is a correlation between AOX dependent respiration and elevated levels of components of the molecular quality control machinery.
