To assess the performance of the MMA relative to the qualitative positive/negative cutoff at 350 MFI, we performed a quantitative analysis of the signal distributions at each site and for each type of signal, positive, negative and endogenous control.
The two children who met the ADOS diagnosis of ASC missed the cutoff of qualitative abnormalities in communication and repetitive behaviors on the ADI-R.
Some of them are simple but qualitative (e.g. cutoff); some are quantitative but insensitive (e.g. relative fraction); some are powerful but instable and hard to be implemented (e.g. learning algorithms).
The chosen pragmatic approach to use a quantitative cutoff for the white matter lesion volume based on the control group might need qualitative refinements.
Additional analysis of the data indicated reduced sensitivity for both the BinaxNOW and FST qualitative tests at the 45% cutoff level.
It is also unsuitable to indicate HBV infection in infants using circulating HBV DNA because the cutoff for the qualitative analysis of HBV DNA depends on the method used.
It is noteworthy that sensitivities and specificities did not differ significantly between qualitative (visual) and quantitative methods (SUVR cutoff automated classification in raised uptake category).
Using 10%, 20%, or 30% of the adjusted male normal value as different cutoffs for deficiency, both qualitative tests were 100% accurate when intermediate results were grouped with G6PD-deficient samples for the FST.
The qualitative evaluation did not allow for a cutoff value between the two groups; however, the distribution in the groups differed significantly.
The results of the IRT paradigm showed that it is possible to go beyond the CTT cutoff point and reach a more qualitative interpretation when a relationship is established between the cutoff point value and the b parameter value of the category of each item.
