Following 2 years of ibandronate treatment, trabecular bone maintained its normal lamellar structure with no evidence of woven bone, marrow fibrosis, cellular toxicity, or other qualitative abnormalities.
There are also some qualitative abnormalities in lipoproteins that appear to control the risk of atherosclerosis and are also associated with familial propensity.
Beyond classical factors, such as low-density lipoprotein (LDL) cholesterol (LDL-C), quabnormalitiesofmalipoproteinspoproteinsuchuch as presence of the atherogenic factor, small dense LDL, may be of interest for a cardiovascular risk assessment.
Qualitative abnormalities were also found in several cases, including T-cell abnormalities in the majority of the EBV-associated HLH cases.
Osteogenesis imperfecta (OI), commonly called "brittle bone disease", is a genetic disorder characterised by increased bone fragility and decreased bone density due to quantitative and/or qualitative abnormalities of type I collagen.
Also known as "brittle bone disease", osteogenesis imperfecta (OI) is a genetic disorder characterised by increased bone fragility and low bone mass density due to quantitative and/or qualitative abnormalities of type I collagen [1, 2].
The interview focuses on the three core or so called "content" domains of autism (i.e. qualitative abnormalities in social interaction (S), qualitative abnormalities in communication (C) and stereotyped and repetitive behaviors (R) [24].
Qualitative abnormalities are however among the predictable consequences of frataxin depletion with impaired iron chaperoning leading to an increase in iron accessibility and intra mitochondrial iron re location favoring iron reaction with oxygen.
While there are many AIS mutations described, those localized in the LBD and associated with 1) normal Kd, 2) normal Bmax, and 3) qualitative abnormalities of ligand-receptor interaction would be the most amenable to normalization.
Several qualitative abnormalities in HDLs have been described in patients with type 2 diabetes.
