Sentence examples for qualified surrogate from inspiring English sources

It will be especially important to apply this revised approach as a biomarker progresses from research tool during early drug development, through proof of principle/concept during early phase trials, until becoming a fully qualified surrogate endpoint that can predict or report drug response in later phase trials, when QC issues become much more crucial (Lee et al, 2005; Cummings et al, 2008).

Discussions with regulatory authorities gain momentum defining the role of tau biomarkers for trial designs and how they may be further qualified for surrogate marker status.

For Rumpole definitely has a domestic side (Holmes's Mrs. Hudson and Poirot's Miss Lemon hardly qualify as surrogate spouses).

In qualifying a surrogate endpoint, specific criteria should be met.

Biomarkers such as drusen volume have not been unequivocally qualified as meaningful surrogate endpoints.

She pointed out that, as part of its evidence-based systemic review, the FDA relies on surrogate endpoints (qualified risk biomarkers) in the premarket scientific review of health claims used for labeling foods and dietary supplements.

Absolute quantification of MRI brain volumes may overcome this limitation for improving neurodevelopmental outcome prediction [11], [12], [13] and qualify as a surrogate endpoint for clinical trials in high risk newborns [13], [14].

In this study, we have set out to test whether quantitative changes in tumour FDG uptake qualify as a surrogate endpoint for predicting the dose-dependent antitumour activity of the mTOR inhibitor everolimus.

Total cholesterol is an example of a clinically useful biomarker that was successfully qualified for use as a surrogate endpoint.

Mr. Lopez said that the surrogate candidates were well qualified and that he would do everything he could to support Justice Johnson.

The need of finding other target-binding molecules as alternatives for antibodies draws the attention now to another surrogate, the aptamer, which is also qualified for target binding [ 1].