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A preliminary overview on the qualification strategy is presented and discussed.
A qualification strategy was defined by a specific combination of a testing scheme, a genotyping scheme and a level of information about flock pedigree.
Prevalence distributions were then used to calculate for each simulated year and qualification strategy, the probability that infection prevalence was below the design prevalence (Eq. 9).
However, there is no general strategy that would always minimize the costs, and in practice, the choice of a qualification strategy should be adapted to genetic conditions (e.g. average resistance level in the breed), as well as to the respective costs of diagnostic tests and genotyping exams.
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Qualification strategies were compared in 50 randomly generated flocks for each of the two preceding populations.
Six qualification strategies were defined that combine genotyping data, diagnostic tests results and flock pedigree.
Qualification strategies were compared in simulated flocks, the genetic trajectories of which were randomly generated.
At each simulated year, the six qualification strategies were successively simulated to compute the six corresponding posterior prevalence distributions.
Several qualification strategies are proposed for demonstrating a flock is free from scrapie (design prevalence: 1%): genotyping-oriented strategies, diagnostic-oriented strategies and pedigree-oriented strategies.
Feasibility of the proposed qualification strategies was quantified, in terms of probability for a scrapie-free simulated flock to be classified as such within a reasonable time.
The goal of this study was to propose, evaluate and compare several qualification strategies for demonstrating a flock is free from scrapie.
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