This study includes activities concerning the testing of computational tools and the qualification of models.
The qualification of models is essential in the use and communication of systems pharmacology models.
In the recently proposed framework for model qualification of physiological models, the first step frames the project questions and the project team agrees on the use of the model inferences for the decision making.
In turn, the qualification of the model depends primarily on the goals of the study that define the qualification criteria and on the usability of the model, rather than on statistics alone.
A thorough qualification of standalone models with respect to biological accuracy ensured physiological behavior when assessed as closed systems.
Therefore, the qualification of the models to do various predictions and the confidence associated with such predictions change over time in parallel with the accumulation and consolidation of the information that goes into the model.
These findings can be considered a first step towards model validation and qualification of this osteoporosis model, which will be further elaborated by also applying the model to other therapeutic interventions.
The test cases executed gradually move from qualification of separate systems models to complete TBS models and from the simulation of steady state and normal plasma pulses operation to consideration of power excursion, operational transients and accident events.
Several models were developed in the course of the Herschel program and this paper deals with the design, manufacturing and qualification of the flight model coolers.
Development and qualification of APAP PBPK model in adults.
