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The ADNI genetic data set was downloaded from the ADNI web site and a similar initial QC process was performed at Pfizer (the final data set after QC includes 509376 markers in 719 subjects).
All the steps used during the QC process are outlined in Table 1.
The same quality control (QC) process was conducted for both groups of data by using PLINK (see supplementary material for detail).
However, more than 60% of the retrieved PWV was rejected through the QC process on the research vessels, while 6 11% was rejected on the passenger ferry.
For today, your take away should be that if you visit a potential manufacturing partner you are going to want to grill them on what their QC process is and any good factory will want to show-off their attention to this aspect of the manufacturing process.
The other BIN1 variant rs744373 was not tested since it was removed from the ADNI data set during the QC process.
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Manufacturing tests cover a range of aspects that include radio calibration and alignment, screening tests during production to detect and weed out defective parts or systems, and postproduction sampling tests for quality control (QC) processes.
(d) Energy level diagram of Ho3+ and Yb3+ showing mechanisms for NIR QC processes.
Raw data were extracted, peak-identified and QC processed using Metabolon's hardware and software [35].
Once the molecular QC system is overwhelmed, organellar QC processes form a second line of defence.
Full details of the iCOGS array design, sample handling and post-genotyping QC processes are described in-depth elsewhere (9).
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